Conventional Cancer Therapies – Low Dose Metronomic Chemotherapy

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Metronomic chemotherapy is one of the biggest steps forward in the history of cancer treatment and is based on the Mikael Nordforsunderstanding of the blood supply in cancer tissue, or rather the possibility of controlling this so that the cancer cannot grow.

For patients, this new method of treatment is very interesting because it has practically no side effects. The treatment primarily uses tablets and research shows that this gives results that are as effective as conventional chemotherapy, in which the highest possible doses are given every second or third week, most often with quite serious side effects.

Angiogenesis means the creation of new blood vessels from an existing blood vessel and this is the primary way in which cancer cells obtain nutrition. Normal chemotherapy also destroys the endothelial cells in the small blood vessels, but is normally interrupted 2-3 weeks between treatment in order to let the body recuperate from serious side effects like nausea, vomiting, bad immune system and diarrhoea. During this time the cancer rebuilds its blood supply.

Metronomic chemotherapy, just like the regular beat of a metronome, is given daily or every second day, and thus does not allow the blood vessels to re-establish. It does not matter which type of cancer cells are involved or even whether they have become resistant. It is not cancer cells themselves which are attacked by metronomic therapy, but the blood vessels supplying the cancer cells.

You may be wondering whether the endothelial cells, too, can become resistant in the long run – and the answer is yes. However it takes a much longer time for the cancer cells to become resistant and the normal process under metronomic treatment is likely to be as follows: At first the tumour becomes smaller, then comes a long and stable period which can last for years until finally the cancer grows again. You can then shift to another form of metronomic chemotherapy or a combination of metronomic substances.